Human Growth/differentiation factor 8

Human growth/differentiation factor 8 (MSTN) is a protein that is involved in the regulation of muscle growth and differentiation. It is a member of the transforming growth factor-beta (TGF-beta) family of proteins, which play a role in the regulation of cell growth and differentiation. MSTN is composed of a signal peptide, a prodomain, and a mature domain that is involved in its function.

MSTN plays a role in the regulation of muscle growth and differentiation by inhibiting the proliferation and differentiation of muscle cells. It does this by interacting with specific receptors on the surface of cells and activating downstream signaling pathways. MSTN has also been found to play a role in the regulation of bone development and the maintenance of bone mass.

There have been a number of recent research studies focused on MSTN and its role in disease development. For example, a study published in the journal Nature Communications in 2021 found that targeting MSTN with small molecule inhibitors was effective in increasing muscle mass and strength in preclinical models of muscle wasting. Another study published in the journal Cell Reports in 2020 found that targeting MSTN with small molecule inhibitors was effective in reducing the formation of bone metastases in preclinical models of breast cancer.