Double stranded RNA

A critical challenge faced during the development and manufacturing of RNA-based therapies is the presence of unintended impurities, particularly double-stranded RNA (dsRNA). While dsRNA is an inevitable byproduct of the in vitro transcription (IVT) process, unchecked contamination can severely jeopardize both the safety and effectiveness of the treatment.

ECHO Bio dsRNA standards and ladders are expertly designed to empower you to benchmark and quantify dsRNA impurities with unparalleled accuracy. These tools are indispensable for:

• Reliable Assessment: Accurately quantify dsRNA contamination throughout your production pipeline.
• Standardized Calibration: Ensure consistent, precise results for all quality control testing.
• Process Optimization: Facilitate robust comparisons to fine-tune purification steps and minimize impurities.

ECHO Bio offers a selection of long dsRNA controls, ideal as reliable standards for your dsRNA detection assays.

• dsRNA500, dsRNA1000, and dsRNA1500 bp: Extended double-stranded RNA molecules available with UTP or N1-Methylpseudouridine-5'-Triphosphate (N1MePsU) modification for robust applications.
• dsRNA hairpin70: A unique single-stranded RNA, also available with UTP or N1-Methylpseudouridine-5'-Triphosphate (N1MePsU), featuring a distinct 3' terminal hairpin.

Why Choose ECHO Bio dsRNA Controls?

• Unmatched Precision & Consistency: Engineered for industry-leading precision, ensuring dependable, reproducible dsRNA assay results.
  Guaranteed Purity: Purity consistently exceeds 80%, validated by capillary electrophoresis (CE), agarose gel electrophoresis (AGE), and size-exclusion chromatography (SEC)
• Broad Versatility & Compatibility: Applicable across diverse research areas and fully compatible with leading dsRNA detection platforms (ELISA, immunoblotting, microfluidic electrophoresis).
• Enhanced Specificity: Demonstrates significantly stronger binding affinity to the dsRNA-specific monoclonal antibody (J2) compared to Poly I:C, with consistent recognition across all molecular weights.