Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | P10912 |
| Gene Names | GHR |
| Alternative Names | Somatotropin receptor |
| Expression Region | Extracellular Domain(19-264aa ) |
| Molecular Weight | 44.4 kDa |
| Protein Sequence | FSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFY |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway |
| Involvement in Disease | Laron syndrome (LARS); Growth hormone insensitivity, partial (GHIP) |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Single-pass type I membrane protein, Note=Remains fixed to the cell membrane and is not internalized, SUBCELLULAR LOCATION: Growth hormone-binding protein: Secreted |
| Protein Families | Type I cytokine receptor family, Type 1 subfamily |
| Tissue Specificity | GHR |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |