Specification
| Organism | Macaca mulatta (Rhesus macaque) |
| Expression Host | E.Coli |
| Tag Info | Tag-Free |
| Purity | >96% as determined by SDS-PAGE and HPLC. |
| Uniprot ID | P51492 |
| Uniprot Entry Name | IL4_MACMU |
| Gene Names | IL4 |
| Alternative Names | IL-4, BSF-1, Lymphocyte stimulatory factor 1 |
| Expression Region | Full Length of Mature Protein (25-153aa) |
| Molecular Weight | 14.9 kDa |
| Endotoxin | Less than 1.0 EU/µg as determined by LAL method. |
| Sequence | HNCHIALREI IETLNSLTEQ KTLCTKLTIT DILAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE DFLERLKTIM REKYSKCSS |
| Product Form | Lyophilized powder (Lyophilized from a 0.2 µm filtered 2 × PBS, pH 7.4, 5 % trehalose) |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). {ECO:0000250}. |
| Function | Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. |
| Involvement in disease | |
| Subcellular Location | Secreted |
| Protein Families | IL-4/IL-13 family |
| Tissue Specificity | |
| Pathway |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |