Specification
Organism | Mus musculus (Mouse) |
Expression Host | Mammalian cell |
Tag Info | C-terminal hFc-tagged |
Purity | Greater than 85% by SDS-PAGE |
Uniprot ID | A8E0Y8 |
Gene Names | Cd101 |
Alternative Names | Glu-Trp-Ile EWI motif-containing protein 101 (EWI-101) (CD_antigen: CD101) (IgSF2) (Igsf2) |
Expression Region | Partial(22-266aa ) |
Molecular Weight | 56.0 kDa |
Protein Sequence | REVKIQEGPLYRAEGYPVSIRCTVSGHQGPSTQDFRWSIYLPSAPTKEVQIISTKDAGFSYAVYAQRVQSKEIYIERLQGDSVLLHISKLQMKDAGEYECHTPNTDGKYFGSYSAKTNLTVVPDTLSATMPSQTLSKKEGEPLELTCETTKATVQHTHLSLTWYLMQEGGGSQATEIVSLSKDFVLTPGSSYADRFVAGDVRLDKLGATSFRLSVGKLQPSDQGQVFCEATEWIQDPDETWTLIT |
Form | Liquid or Lyophilization |
Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
Relevance | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. |
Involvement in Disease | |
Subcellular Location | Membrane, Single-pass type I membrane protein |
Protein Families | |
Tissue Specificity | Cd101 |
QC Data
Note | Please contact us for QC Data |
Product Image (Reference Only) | ![]() |