Specification
| Organism | Mus musculus (Mouse) |
| Expression Host | E.Coli |
| Tag Info | Tag-Free |
| Purity | >97% as determined by SDS-PAGE and HPLC. |
| Uniprot ID | O35188 |
| Uniprot Entry Name | X3CL1_MOUSE |
| Gene Names | Cx3cl1,Cx3c,Fkn,Scyd1 |
| Alternative Names | C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, , |
| Expression Region | Partial (25-100aa) |
| Molecular Weight | 8.7 kDa |
| Endotoxin | Less than 1.0 EU/µg as determined by LAL method. |
| Sequence | QHLGMTKCEI MCGKMTSRIP VALLIRYQLN QESCGKRAIV LETTQHRRFC ADPKEKWVQD AMKHLDHQAA ALTKNG |
| Product Form | Lyophilized powder (Lyophilized from a 0.2 µm filtered PBS, pH 7.4) |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (By similarity). Binds to CX3CR1. {ECO:0000250}. |
| Function | Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV |
| Involvement in disease | |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted |
| Protein Families | Intercrine delta family |
| Tissue Specificity | Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis. |
| Pathway |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |