Specification
| Description | Recombinant protein of the mature form (Leu23 - Ile314) of Mus musculus fibrinogen like 1 (FGL1) (NM_145594). |
| Organism | Mus musculus (Mouse) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q71KU9 |
| Entry Name | FGL1_MOUSE |
| Gene Names | Fgl1 Mfire1 |
| Alternative Gene Names | Mfire1 |
| Alternative Protein Names | Fibrinogen-like protein 1 (Fibrinogen-related protein 1) (Mfrep-1) (Liver fibrinogen-related protein-1) (Mfire-1) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 314 |
| Molecular Weight(Da) | 36439 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MGKIYSFVLVAIALMMGREGWALESESCLREQVRLRAQVHQLETRVKQQQTMIAQLLHEKEVQFLDKGSENSFIDLGGKRQYADCSEIYNDGFKQSGFYKIKPLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQNNGEYWLGNKNINLLTIQGDYTLKIDLTDFEKNSSFAQYQSFKVGDKKSFYELNIGEYSGTAGDSLSGTFHPEVQWWASHQRMKFSTWDRDNDNYQGNCAEEEQSGWWFNRCHSANLNGVYYRGSYRAETDNGVVWYTWHGWWYSLKSVVMKIRPSDFIPNII |
Background
| Function | FUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q08830, ECO:0000269|PubMed:30580966}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Mainly expressed in liver (PubMed:12528893, PubMed:23483972). Also expressed in brown adipose tissue (PubMed:23483972). {ECO:0000269|PubMed:12528893, ECO:0000269|PubMed:23483972}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |