Specification
| Organism | Lassa virus (strain GA391) (LASV) |
| Expression Host | Baculovirus |
| Tag Info | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | P04935 |
| Gene Names | N |
| Alternative Names | Nucleocapsid protein Protein N |
| Expression Region | Full Length(1-570aa ) |
| Molecular Weight | 66.8 kDa |
| Protein Sequence | MSASKEVRSCLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKQKRDDGDLKRLRDLNQAVNNLVELKSTQQKSVLRVGTLSSDDLLILAADLEKLKSKVTRTERPLSSGVYMGNLSSQQLDQRRALLNMIGMTGVSGGGKGASNGIVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNSSDLDRLSQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETIKVSPQTMDGILKSILKVKKSLGMFVSDTPGERNPYENILYKICLSGDGWSYIASRTSIVGRAWENTVVDLEQDNKPQKIGNGGSNKSLQSAGFAAGLIYSQLMTLKDFKCFNLIPNAKTWMDIEGRPEDPVEIALYQPSSGCYVHFFREPTDLKQFKQDAKYSHGRDVTDLFAAQPGLTSAVIEALPRNMVITCQGSEDIRKLLESQGRRDIKLIDITLSKADSRKFENAVWDQFKDLCHMHTGVVVEKKKRGGKEEITPHCALMDCIMFDAAVSGGLDAKVLRVVLPRDMVFRTSTPKVVL |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. |
| Involvement in Disease | |
| Subcellular Location | |
| Protein Families | |
| Tissue Specificity | N |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |