Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | P09936 |
| Gene Names | UCHL1 |
| Alternative Names | Neuron Cytoplasmic domain protein 9.5PGP 9.5 ;PGP9.5Ubiquitin thioesterase L1 |
| Expression Region | Partial(1-222aa ) |
| Molecular Weight | 28.8 kDa |
| Protein Sequence | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKA |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. |
| Involvement in Disease | Parkinson disease 5 (PARK5); Spastic paraplegia 79, autosomal recessive (SPG79) |
| Subcellular Location | Cytoplasm, Endoplasmic reticulum membrane, Lipid-anchor |
| Protein Families | Peptidase C12 family |
| Tissue Specificity | UCHL1 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |