Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens transmembrane protein 120A (TMEM120A), transcript variant 1 (NM_031925). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9BXJ8 |
| Entry Name | TACAN_HUMAN |
| Gene Names | TMEM120A TACAN TMPIT |
| Alternative Gene Names | TACAN TMPIT |
| Alternative Protein Names | Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 343 |
| Molecular Weight(Da) | 40610 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQNNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAAQELENQMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLAQDPQCKEWQVLMCGFPFLLLFLGNFFTTLRVVHHKFHSQRHGSKKD |
Background
| Function | FUNCTION: Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229). {ECO:0000250|UniProtKB:Q8C1E7, ECO:0000269|PubMed:26024229}. |
| Pathway | |
| Protein Families | TMEM120 family |
| Tissue Specificity | Expressed in nociceptors. {ECO:0000269|PubMed:32084332}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |