Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal GST-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | Q86XR7 |
| Gene Names | TICAM2 |
| Alternative Names | Putative NF-kappa-B-activating protein 502 TRIF-related adapter molecule Toll-like receptor adaptor protein 3 Toll/interleukin-1 receptor domain-containing protein |
| Expression Region | Full Length of Mature Protein(2-235aa ) |
| Molecular Weight | 53.8 kDa |
| Protein Sequence | GIGKSKINSCPLSLSWGKRHSVDTSPGYHESDSKKSEDLSLCNVAEHSNTTEGPTGKQEGAQSVEEMFEEEAEEEVFLKFVILHAEDDTDEALRVQNLLQDDFGIKPGIIFAEMPCGRQHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPLNNPLPRERTPFALQTINALEEESRGFPTQVERIFQESVYKTQQTIWKETRNMVQRQFIA |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
| Involvement in Disease | |
| Subcellular Location | Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic reticulum, Early endosome membrane, Late endosome membrane, Note=Localized to the plasma membrane as a result of myristoylation, Phosphorylation on Ser-16 leads to its depletion from the membrane, Upon LPS stimulation colcoalizes with isoform 2 in late endosomes, SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum, Early endosome membrane, Late endosome membrane |
| Protein Families | |
| Tissue Specificity | TICAM2 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |