Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens regulator of G protein signaling 19 (RGS19), transcript variant 2 (NM_001039467). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | P49795 |
| Entry Name | RGS19_HUMAN |
| Gene Names | RGS19 GAIP GNAI3IP |
| Alternative Gene Names | GAIP GNAI3IP |
| Alternative Protein Names | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 217 |
| Molecular Weight(Da) | 24636 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA |
Background
| Function | FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |