Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal GST-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | O15162 |
| Gene Names | PLSCR1 |
| Alternative Names | Ca(2+)-dependent phospholipid scramblase 1 Erythrocyte phospholipid scramblase MmTRA1b |
| Expression Region | Full Length(1-318aa ) |
| Molecular Weight | 28.4 kDa |
| Protein Sequence | ESTGSQEQKSGVW |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. |
| Involvement in Disease | |
| Subcellular Location | Cell membrane, Single-pass type II membrane protein, Membrane, Lipid-anchor, Cytoplasmic side, Nucleus |
| Protein Families | Phospholipid scramblase family |
| Tissue Specificity | PLSCR1 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |