Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | Q8WYR1 |
| Gene Names | PIK3R5 |
| Alternative Names | PI3-kinase p101 subunitPhosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit ;PtdIns-3-kinase regulatory subunitProtein FOAP-2;PtdIns-3-kinase p101p101-PI3K |
| Expression Region | Full Length of Isoform 2 (1-494aa ) |
| Molecular Weight | 70.9 kDa |
| Protein Sequence | MDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma mbrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG . |
| Involvement in Disease | Ataxia-oculomotor apraxia 3 (AOA3) |
| Subcellular Location | Nucleus, Cytoplasm, Cell membrane, Peripheral membrane protein |
| Protein Families | |
| Tissue Specificity | PIK3R5 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |