Specification
| Description | Recombinant protein from the full-length sequence of homo sapiens nuclear VCP-like (NVL), transcript variant 1 (NM_002533). |
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli/Yeast/Insect |
| Tag Info | Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 85% by SDS-PAGE gel |
| Uniprot ID | O15381 |
| Entry Name | NVL_HUMAN |
| Gene Names | NVL NVL2 |
| Alternative Gene Names | NVL2 |
| Alternative Protein Names | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein);Nuclear valosin containing protein like; Nuclear valosin-containing protein-like; Nuclear VCP like; Nuclear VCP-like protein; Nvl; NVL_HUMAN; NVLp; OTTHUMP00000035641; OTTHUMP00000216593; OTTHUMP00000216594; OTTHUMP00000216599; OTTHUMP00000216600 |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Tris/PBS-based buffer, 6% Trehalose, pH8, or other buffer specified by customer |
| Form | Lyophilized Powder or Other form specified by Customer |
| Endotoxin | N/A |
| Length | Partial |
| Molecular Weight(Da) | TBD |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MKPRPAGFVDNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQSANHMNSSLLSLYRKGNPDSVSNTPEMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRK |
Background
| Function | FUNCTION: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. |
| Pathway | |
| Protein Families | AAA ATPase family |
| Gene References |
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| Subcellular Location | [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. |
| Tissue Specificity | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. {ECO:0000269|PubMed:9286697}. |
QC Data
| Please contact us for specific QC data. |