Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | Q14994 |
| Gene Names | NR1I3 |
| Alternative Names | Constitutive activator of retinoid response ;Constitutive active responseConstitutive androstane receptor ;CAROrphan nuclear receptor MB67 |
| Expression Region | Partial(2-351aa ) |
| Molecular Weight | 55.7 kDa |
| Protein Sequence | ASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEIC |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Binds and transactivates the retinoic acid response elents that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive elent module of the human CYP2B6 gene and the CYP3A4 xenobiotic response elent. |
| Involvement in Disease | |
| Subcellular Location | Nucleus, Cytoplasm, Cytoplasm, cytoskeleton |
| Protein Families | Nuclear hormone receptor family, NR1 subfamily |
| Tissue Specificity | NR1I3 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |