Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens nuclear casein kinase and cyclin dependent kinase substrate 1 (NUCKS1) (NM_022731). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9H1E3 |
| Entry Name | NUCKS_HUMAN |
| Gene Names | NUCKS1 NUCKS JC7 |
| Alternative Gene Names | NUCKS |
| Alternative Protein Names | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 243 |
| Molecular Weight(Da) | 27296 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSRPVRNRKVVDYSQFQESDDADEDYGRDSGPPTKKIRSSPREAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAASKQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSKPERKEKKMPKPRLKATVTPSPVKGKGKVGRPTASKASKEKTPSPKEEDEEPESPPEKKTSTSPPPEKSGDEGSEDEAPSGED |
Background
| Function | FUNCTION: Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung. {ECO:0000269|PubMed:15381070}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |