Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.Coli |
| Tag Info | Tag-Free |
| Purity | >96% as determined by SDS-PAGE and HPLC. |
| Uniprot ID | P01374 |
| Uniprot Entry Name | TNFB_HUMAN |
| Gene Names | LTA,TNFB,TNFSF1 |
| Alternative Names | LT-alpha, Tumor necrosis factor ligand superfamily member 1 |
| Expression Region | Full Length of Mature Protein (35-205aa) |
| Molecular Weight | 18.7 kDa |
| Endotoxin | Less than 1.0 EU/µg as determined by LAL method. |
| Sequence | LPGVGLTPSA AQTARQHPKM HLAHSTLKPA AHLIGDPSKQ NSLLWRANTD RAFLQDGFSL SNNSLLVPTS GIYFVYSQVV FSGKAYSPKA TSSPLYLAHE VQLFSSQYPF HVPLLSSQKM VYPGLQEPWL HSMYHGAAFQ LTQGDQLSTH TDGIPHLVLS PSTVFFGAFA L |
| Product Form | Lyophilized powder (Lyophilized from a 0.2 µm filtered PBS, pH7.4, with 0.02 % Tween-20) |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Involvement in disease | Psoriatic arthritis (PSORAS) |
| Subcellular Location | Secreted, Membrane |
| Protein Families | Tumor necrosis factor family |
| Tissue Specificity | |
| Pathway | NF-kappaBsignalingpathway |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |