Specification
| Description | Recombinant protein from human LAP3 (NP_056991.2) (Met1-Ala519). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His Tag. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | P28838 |
| Entry Name | AMPL_HUMAN |
| Gene Names | LAP3 LAPEP PEPS |
| Alternative Gene Names | LAPEP PEPS |
| Alternative Protein Names | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Form | Lyophilized |
| Buffer | Sterile 20mM Tris,500 mM NaCl,20% glycerol,pH7.4. Normally 5%-8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | Consists 530 amino acids and |
| Molecular Weight(Da) | Predicts a molecular mass of 57.6 kDa. |
| Protein Sequence | Please contact us for the exact sequence. |
Background
| Function | FUNCTION: Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}. |
| Pathway | |
| Protein Families | Peptidase M17 family |
| Tissue Specificity |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |