Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens inflammation and lipid regulator with UBA-like and NBR1-like domains (ILRUN), transcript variant 2 (NM_022758). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9H6K1 |
| Entry Name | ILRUN_HUMAN |
| Gene Names | ILRUN C6orf106 |
| Alternative Gene Names | C6orf106 |
| Alternative Protein Names | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 298 |
| Molecular Weight(Da) | 32872 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS |
Background
| Function | FUNCTION: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Expressed in lung (at protein level). {ECO:0000269|PubMed:25736925}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |