Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens interleukin 31 (IL31) (NM_001014336). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q6EBC2 |
| Entry Name | IL31_HUMAN |
| Gene Names | IL31 |
| Alternative Gene Names | |
| Alternative Protein Names | Interleukin-31 (IL-31) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 164 |
| Molecular Weight(Da) | 18205 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MASHSGPSTSVLFLFCCLGGWLASHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT |
Background
| Function | FUNCTION: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). {ECO:0000250|UniProtKB:Q6EAL8, ECO:0000269|PubMed:15184896}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. {ECO:0000269|PubMed:15184896}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |