Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal GST-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | O60506 |
| Gene Names | SYNCRIP |
| Alternative Names | Glycine- and tyrosine-rich RNA-binding protein ;GRY-RBPNS1-associated protein 1Synaptotagmin-binding, Cytoplasmic domain RNA-interacting protein |
| Expression Region | Partial(2-191aa ) |
| Molecular Weight | 47.8 kDa |
| Protein Sequence | ATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDL |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complentation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in Cytoplasmic domain vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assbles into the GAIT complex which binds to st loop-containing GAIT elents in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; ses not to be essential for GAIT complex function. |
| Involvement in Disease | |
| Subcellular Location | Cytoplasm, Microsome, Endoplasmic reticulum, Nucleus, Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity), Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity), SUBCELLULAR LOCATION: Isoform 1: Nucleus, nucleoplasm, Note=Expressed predominantly in the nucleoplasm, SUBCELLULAR LOCATION: Isoform 2: Nucleus, nucleoplasm, Note=Expressed predominantly in the nucleoplasm, SUBCELLULAR LOCATION: Isoform 3: Nucleus, nucleoplasm |
| Protein Families | |
| Tissue Specificity | SYNCRIP |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |