Specification
| Organism | Homo sapiens (Human) |
| Expression Host | Yeast |
| Tag Info | N-terminal 6xHis-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | Q8TDQ0 |
| Gene Names | HAVCR2 |
| Alternative Names | T-cell immunoglobulin and mucin domain-containing protein 3 ;TIMD-3T-cell immunoglobulin mucin receptor 3 ;TIM-3T-cell membrane protein 3 |
| Expression Region | Extracellular Domain(22-202aa ) |
| Molecular Weight | 22 kDa |
| Protein Sequence | SEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIG |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. |
| Involvement in Disease | May be involved in T-cell exhaustion associated with chronic viral infections such as with human immunodeficiency virus (HIV) and hepatitic C virus (HCV). |
| Subcellular Location | Membrane, Single-pass type I membrane protein, Cell junction |
| Protein Families | Immunoglobulin superfamily, TIM family |
| Tissue Specificity | HAVCR2 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |