Recombinant Human E3 ubiquitin-protein ligase RNF13(RNF13),partial

Specification
Organism Homo sapiens (Human)
Expression Host E.coli
Protein Tag N-terminal 10xHis-tagged
Purity Greater than 85% as determined by SDS-PAGE.
Endotoxin Level Not test.
Biological Activity
Uniprot ID O43567
Gene Names RNF13
Alternative Names (RING finger protein 13)(RING-type E3 ubiquitin transferase RNF13)
Expression Region 204-381aa
Product Form Liquid or Lyophilized powder
Buffer The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.31 if the delivery form is lyophilized powder. Please contact us if you have any special requirment.
Reconstitution Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-123℃.
Protein Length Partial
Molecular Weight 26.2 kDa
Protein Sequence TKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSESRSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV
Background
Research Areas Cell Biology
Relevance E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA .
Function
Reference "Heterozygous RNF13 gain-of-function variants are associated with congenital microcephaly, epileptic encephalopathy, blindness, and failure to thrive." Edvardson S., Nicolae C.M., Noh G.J., Burton J.E., Punzi G., Shaag A., Bischetsrieder J., De Grassi A., Pierri C.L., Elpeleg O., Moldovan G.L. Am. J. Hum. Genet. 104:179-185(2019)
QC Data
Note Please contact us for QC Data
Product Image (Reference Only) Product via image
$298.00
In stock
SKU
EB-N231044

Protein expressed from mulitple host is available with various size. Please inquiry us if you need any customized needs.

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