Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | Q16854 |
| Gene Names | DGUOK |
| Alternative Names | DGUOK; DGK; Deoxyguanosine kinase; mitochondrial; dGK; EC 2.7.1.113 |
| Expression Region | Full Length of Mature Protein(40-277aa ) |
| Molecular Weight | 44 kDa |
| Protein Sequence | RLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely ployed as antiviral and chotherapeutic agents. |
| Involvement in Disease | Mitochondrial DNA depletion syndrome 3 (MTDPS3); Portal hypertension, non-cirrhotic (NCPH); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 (PEOB4) |
| Subcellular Location | Mitochondrion |
| Protein Families | DCK/DGK family |
| Tissue Specificity | DGUOK |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |