Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens COMM domain containing 3 (COMMD3) (NM_012071). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9UBI1 |
| Entry Name | COMD3_HUMAN |
| Gene Names | COMMD3 BUP C10orf8 |
| Alternative Gene Names | BUP C10orf8 |
| Alternative Protein Names | COMM domain-containing protein 3 (Protein Bup) (Protein PIL) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 195 |
| Molecular Weight(Da) | 22151 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLKDASKSLERATQL |
Background
| Function | FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Widely expressed with highest expression in thymus. {ECO:0000269|PubMed:15799966}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |