Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens cytosolic iron-sulfur assembly component 2A (CIAO2A), transcript variant 1 (NM_032231). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9H5X1 |
| Entry Name | CIA2A_HUMAN |
| Gene Names | CIAO2A CIA2A FAM96A |
| Alternative Gene Names | CIA2A FAM96A |
| Alternative Protein Names | Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 160 |
| Molecular Weight(Da) | 18355 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEEEYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLREIVEQCVLEPD |
Background
| Function | FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227). {ECO:0000250, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:25716227}. |
| Pathway | |
| Protein Families | MIP18 family |
| Tissue Specificity | Substantially enriched in macrophages. {ECO:0000269|PubMed:22683786}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |