Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens coiled-coil domain containing 115 (CCDC115), transcript variant 1 (NM_032357). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q96NT0 |
| Entry Name | CC115_HUMAN |
| Gene Names | CCDC115 |
| Alternative Gene Names | |
| Alternative Protein Names | Coiled-coil domain-containing protein 115 |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 180 |
| Molecular Weight(Da) | 19761 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA |
Background
| Function | FUNCTION: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). {ECO:0000269|PubMed:26833332, ECO:0000269|PubMed:28296633}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Expressed throughout the brain. {ECO:0000269|PubMed:16378758}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |