Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens BH3 interacting domain death agonist (BID), transcript variant 1 (NM_197966). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | P55957 |
| Entry Name | BID_HUMAN |
| Gene Names | BID |
| Alternative Gene Names | |
| Alternative Protein Names | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 195 |
| Molecular Weight(Da) | 21995 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD |
Background
| Function | FUNCTION: Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737). Allows the release of cytochrome c (By similarity). {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:15661737}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269|PubMed:14583606}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | [Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level). {ECO:0000269|PubMed:14583606}.; TISSUE SPECIFICITY: [Isoform 3]: Expressed in lung, pancreas and spleen (at protein level). {ECO:0000269|PubMed:14583606}.; TISSUE SPECIFICITY: [Isoform 4]: Expressed in lung and pancreas (at protein level). {ECO:0000269|PubMed:14583606}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |