Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.Coli |
| Tag Info | Tag-Free |
| Purity | >98% as determined by SDS-PAGE and HPLC. |
| Uniprot ID | O15263 |
| Uniprot Entry Name | DFB4A_HUMAN |
| Gene Names | DEFB4A,DEFB102,DEFB2,DEFB4;,DEFB4B |
| Alternative Names | Beta-defensin 2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1 |
| Expression Region | Full Length of Mature Protein (24-64aa) |
| Molecular Weight | 4.3 kDa |
| Endotoxin | Less than 1.0 EU/µg as determined by LAL method. |
| Sequence | GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P |
| Product Form | Lyophilized powder (Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl) |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Has antibacterial activity. {ECO:0000305}. |
| Function | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells |
| Involvement in disease | |
| Subcellular Location | Secreted |
| Protein Families | Beta-defensin family, LAP/TAP subfamily |
| Tissue Specificity | Expressed in the skin and respiratory tract. |
| Pathway |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |