Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens 3-hydroxybutyrate dehydrogenase 2 (BDH2) (NM_020139). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9BUT1 |
| Entry Name | BDH2_HUMAN |
| Gene Names | BDH2 DHRS6 SDR15C1 UNQ6308/PRO20933 |
| Alternative Gene Names | DHRS6 SDR15C1 |
| Alternative Protein Names | 3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA) (R-beta-hydroxybutyrate dehydrogenase) (Short chain dehydrogenase/reductase family 15C member 1) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 245 |
| Molecular Weight(Da) | 26724 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDGGWSL |
Background
| Function | FUNCTION: Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). {ECO:0000250|UniProtKB:Q8JZV9, ECO:0000269|PubMed:16380372}. |
| Pathway | Siderophore biosynthesis. |
| Protein Families | Short-chain dehydrogenases/reductases (SDR) family |
| Tissue Specificity | Detected in liver (at protein level). {ECO:0000269|PubMed:22527885}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |