Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 4 (NM_014417). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9BXH1 |
| Entry Name | BBC3_HUMAN |
| Gene Names | BBC3 PUMA |
| Alternative Gene Names | PUMA |
| Alternative Protein Names | Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 193 |
| Molecular Weight(Da) | 20532 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN |
Background
| Function | FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338). {ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:23340338}. |
| Pathway | |
| Protein Families | Bcl-2 family |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11463391}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |