Specification
| Organism | Homo sapiens (Human) |
| Expression Host | E.coli |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | O95999 |
| Gene Names | BCL10 |
| Alternative Names | B-cell CLL/lymphoma 10 ;hCLAPCED-3/ICH-1 prodomain homologous E10-like regulator ;CIPER;Cellular homolog of vCARMEN ;cCARMENCellular-E10 ;c-E10Mammalian CARD-containing adapter molecule E10 ;mE10 |
| Expression Region | Full Length(1-233aa ) |
| Molecular Weight | 42.3 kDa |
| Protein Sequence | MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Involved in adaptive immune response . Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 . |
| Involvement in Disease | Immunodeficiency 37 (IMD37); Lymphoma, mucosa-associated lymphoid type (MALTOMA) |
| Subcellular Location | Cytoplasm, perinuclear region, Membrane raft |
| Protein Families | |
| Tissue Specificity | BCL10 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |