Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens axin interactor, dorsalization associated (AIDA) (NM_022831). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q96BJ3 |
| Entry Name | AIDA_HUMAN |
| Gene Names | AIDA C1orf80 |
| Alternative Gene Names | C1orf80 |
| Alternative Protein Names | Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 306 |
| Molecular Weight(Da) | 35023 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSEVTRSLLQRWGASFRRGADFDSWGQLVEAIDEYQILARHLQKEAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNILTYNKEFPFDVQPVPLRRILAPGEEENLEFEEDEEEGGAGAGSPDSFPARVPGTLLPRLPSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYVHFNVDIELQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELYKKPTDFKRKKLQLLTKKPLYLHLHQTLHKE |
Background
| Function | FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}. |
| Pathway | |
| Protein Families | AIDA family |
| Tissue Specificity | Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. {ECO:0000269|PubMed:17681137}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |