Specification
| Organism | Drosophila melanogaster (Fruit fly) |
| Expression Host | Yeast |
| Tag Info | Tag-Free |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | P05623 |
| Gene Names | SP |
| Alternative Names | Paragonial peptide B Sex peptide Short name: SP |
| Expression Region | Full Length of Mature Protein(20-55aa ) |
| Molecular Weight | 4.3 kDa |
| Protein Sequence | WEWPWNRKPTKFPIPSPNPRDKWCRLNLGPAWGGRC |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:3135120, PubMed:19249273, PubMed:20308537, PubMed:19793753, PubMed:15694303, PubMed:24089336). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20458515, PubMed:20308537, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:3135120, PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336). |
| Involvement in Disease | |
| Subcellular Location | Secreted |
| Protein Families | Drosophila sex peptide family |
| Tissue Specificity | SP |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |