Specification
| Organism | Centruroides elegans (Bark scorpion) |
| Expression Host | Baculovirus |
| Tag Info | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Purity | Greater than 85% by SDS-PAGE |
| Uniprot ID | P0CH40 |
| Gene Names | N/A |
| Alternative Names | Beta-toxin CeII8 |
| Expression Region | Full Length(1-64aa ) |
| Molecular Weight | 11.3 |
| Protein Sequence | KKDGYPVNMEECRYNCWKNAYCDKLCKEKKGQSGYCYGWNLSCWCIGLPDNTNTKMNPFCQTAD |
| Form | Liquid or Lyophilization |
| Buffer | The default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol if the delivery form is liquid. The lyophilization buffer is Tris/PBS-based buffer, 6% Trehalose, pH 8.0 if the delivery form is lyophilized powder. Please contact us if you have any special requirment. |
| Reconstitution | Please reconstitute protein in deionized sterile water and we recommend that briefly centrifuge thevial prior to opening the vial .We recommend aliquot for long-term storage at -20℃/-80℃. |
Background
| Relevance | Beta toxins bind at site-4 of sodium channels and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Has a selective effect toward Nav1.7/SCN9A which plays a role in pain mechanisms, and especially in the development of inflammatory pain. Shows no lethality toward mice. |
| Involvement in Disease | |
| Subcellular Location | |
| Protein Families | |
| Tissue Specificity | N/A |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |