Specification
| Alternative Names | SARM1 |
| Uniprot ID | Q6SZW1 |
| Tag | C-terminal Flag-tagged |
| Size | 1 vial contains approximately 5x106 cells in 1 ml |
| Screening Marker | Puromycin |
| Culture Media | DMEM + 10% FBS + 2μg/mL Puromycin |
| Buffer | 35% FBS + 55% DMEM + 10% DMSO |
| Tested Application | Binding assay by FACS and Western blot |
| Storage | Frozen in liquid nitrogen or stored at -80°C |
Background
| Function | HEK293T/Human SARM1 Stable Cell Line - Cusabio |
| Subcellular Location | Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. |
| Tissue Specificity | Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta. |
| Protein Family | |
| References | we identify a physical interaction between the autoinhibitory N terminus and the TIR domain of SARM1, revealing a previously unrecognized direct connection between these domains that we propose mediates autoinhibition and activation upon injury. PMID: 27671644 Active nerve degeneration requires SARM1 and MAP kinases, including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration. PMID: 26844829 Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions. PMID: 26592460 These results indicate that association of PINK1 with SARM1 and TRAF6 is an important step for mitophagy. PMID: 23885119 The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PMID: 23923041 Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1. PMID: 24840802 Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis. PMID: 24021647 SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon. PMID: 23175186 The N-terminal 27 amino acids (S27) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 peptide has an inherent ability to bind to lipids and mitochondria. PMID: 22145856 SARM-mediated inhibition may not be exclusively directed at TRIF or MyD88, but that SARM may also directly inhibit MAPK phosphorylation PMID: 20306472 Candidate gene in the onset of hereditary infectious/inflammatory diseases. PMID: 15893701 TIR adaptor SARM is a negative regulator of Toll-like receptor signaling. PMID: 16964262 confirmed the co-localization of retinoschisin with Na/K ATPase and SARM1 in photoreceptors and bipolar cells of retina tissue PMID: 17804407 SARM1 deficiencies may uncover unexpected similarities between the ways in which neurons and immune cells sense and respond to danger. PMID: 18089857 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |