Specification
| Alternative Names | ENPP3 |
| Uniprot ID | O14638 |
| Tag | Tag-Free |
| Size | 1 vial contains approximately 5x106 cells in 1 ml |
| Screening Marker | Puromycin |
| Culture Media | DMEM + 10% FBS + 2μg/mL Puromycin |
| Buffer | 35% FBS + 55% DMEM + 10% DMSO |
| Tested Application | Binding assay by FACS and cell based ELISA. |
| Storage | Frozen in liquid nitrogen or stored at -80°C |
Background
| Function | Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted. |
| Tissue Specificity | Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils. |
| Protein Family | Nucleotide pyrophosphatase/phosphodiesterase family |
| References | Functions We showed the ability of the immunological marker CD203c to predict the clinical efficacy of sublingual immunotherapy on rhinitis subjects allergic to Parietaria. PMID: 29702283 Basophil CD203c surface expression reliably discriminated cystic fibrosis with allergic bronchopulmonary aspergillosis from cystic fibrosis with Aspergillus colonization and cystic fibrosis over time. PMID: 26585435 Expression of CD203c on basophils as a marker of immunoglobulin E-mediated (L)-asparaginase allergy. PMID: 23581640 Anaphylactic transfusion reaction in homozygous haptoglobin deficiency detected by CD203c expression on basophils. PMID: 24497482 ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) PMID: 23960081 |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |