ADC-Screener™ Anti-Human IgG Fc, VHH(VcMMAE)

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Specification
Background
QC Data

Specification

Specificity	Recognizes human IgG Fcγ fragment specifically, and reacts with cynomolgus IgG. No Cross-reactivity to rabbit , mouse, rat, goat IgG
Host	Alpaca pacous
Applications	Antibody Internalization assay
Storage	Store at –20 °C(Avoid freeze / thaw cycles)
Isotype	VHH domain of alpaca IgG2b/2c
Purification	Recombinant Expression and Affinity purified
Concentration	0.5mg/ml
Cross-Reactivity	Human IgG(Fcγ fragment specific), including IgG1, IgG2, IgG3, IgG4 and their mutations(LALA or YTE)
Formulation	Liquid, 10mM PBS (pH 7.4)
Conjugate	VcMMAF
Advantages	High lot-to-lot consistency * Increased sensitivity and higher affinity * Animal-free production
Reactivity	Human IgG(Fcγ Fragment specific)
Immunogen	Recombinant Fc region of human IgG

Specification
Background
QC Data

Background

ADC-Screener™ Anti-Human IgG Fc, VHH(VcMMAF ×8) is designed to evaluate the internalization kinetics and therapeutic potential of human IgG antibodies. It consists of VcMMAF—coupled to a high-affinity recombinant VHH specific to the human IgG Fc region.

This tool is highly effective for screening antibody leads for ADC applications, as cytotoxicity is only triggered upon successful endocytosis. The 60 kDa recombinant complex ensures minimal steric interference while providing high sensitivity in cell-based potency assays.

Specification
Background
QC Data

QC Data

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SKU

EB-AN-0849

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ADC-Screener™ Anti-Human IgG Fc, VHH(VcMMAE)

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