Human Myc proto-oncogene protein(MYC)

The MYC gene encodes a nuclear phosphoprotein that is involved in the regulation of cell cycle progression, apoptosis, and cellular transformation. It forms a complex with the related transcription factor MAX and binds to specific DNA sequences called E boxes, which control the transcription of certain target genes.

Amplification of the MYC gene is common in various types of cancer, and genetic abnormalities involving the MYC gene are associated with Burkitt lymphoma and multiple myeloma in humans. The MYC protein can be produced from two different start sites, resulting in the production of two isoforms with different N-termini. The MYC gene is classified as a proto-oncogene, which means that it has the potential to cause cancer when it is overactive or mutated.