Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens Ras homolog, mTORC1 binding (RHEB) (NM_005614). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q15382 |
| Entry Name | RHEB_HUMAN |
| Gene Names | RHEB RHEB2 |
| Alternative Gene Names | RHEB2 |
| Alternative Protein Names | GTP-binding protein Rheb (Ras homolog enriched in brain) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 184 |
| Molecular Weight(Da) | 20497 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM |
Background
| Function | FUNCTION: Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}. |
| Pathway | |
| Protein Families | Small GTPase superfamily, Rheb family |
| Tissue Specificity | Ubiquitous. Highest levels observed in skeletal and cardiac muscle. {ECO:0000269|PubMed:8543055}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |