Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens Rac family small GTPase 3 (RAC3), transcript variant 1 (NM_005052). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | P60763 |
| Entry Name | RAC3_HUMAN |
| Gene Names | RAC3 |
| Alternative Gene Names | |
| Alternative Protein Names | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 192 |
| Molecular Weight(Da) | 21379 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF |
Background
| Function | FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}. |
| Pathway | |
| Protein Families | Small GTPase superfamily, Rho family |
| Tissue Specificity | Highest levels in brain, also detected in heart, placenta and pancreas. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |