Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens proline rich acidic protein 1 (PRAP1), transcript variant 2 (NM_001145201). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q96NZ9 |
| Entry Name | PRAP1_HUMAN |
| Gene Names | PRAP1 UPA UNQ608/PRO1195 |
| Alternative Gene Names | UPA |
| Alternative Protein Names | Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 151 |
| Molecular Weight(Da) | 17208 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ |
Background
| Function | FUNCTION: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459). May downregulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861). {ECO:0000250|UniProtKB:Q80XD8, ECO:0000269|PubMed:14583459, ECO:0000269|PubMed:23235459, ECO:0000269|PubMed:24374861}. |
| Pathway | |
| Protein Families | |
| Tissue Specificity | Highly expressed in the intestinal epithelial cells (at protein level) (PubMed:32629119). Abundantly expressed in the epithelial cells of the liver, kidney and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:14583459, ECO:0000269|PubMed:20736409, ECO:0000269|PubMed:24374861, ECO:0000269|PubMed:32629119}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |