Specification
Description | Recombinant protein from the full-length sequence of Homo sapiens olfactory receptor family 51 subfamily E member 2 (OR51E2) (NM_030774). |
Organism | Homo sapiens (Human) |
Expression Host | Human Cells |
Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
Purity | Greater than 90% by SDS-PAGE gel |
Uniprot ID | Q9H255 |
Entry Name | O51E2_HUMAN |
Gene Names | OR51E2 PSGR |
Alternative Gene Names | PSGR |
Alternative Protein Names | Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor) |
Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
Length | 320 |
Molecular Weight(Da) | 35493 |
Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK |
Background
Function | FUNCTION: Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity). {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}. |
Pathway | |
Protein Families | G-protein coupled receptor 1 family |
Tissue Specificity | Highly expressed in the prostate (PubMed:11707321). Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:29249973, PubMed:11707321, PubMed:16491480). In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973). Expressed in epidermal melanocytes (at protein level) (PubMed:27226631). {ECO:0000269|PubMed:11707321, ECO:0000269|PubMed:16491480, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}. |
QC Data
Note | Please contact us for QC Data |
Product Image (Reference Only) | ![]() |