Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens methyltransferase like 18 (METTL18), transcript variant 1 (NM_033418). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | O95568 |
| Entry Name | MET18_HUMAN |
| Gene Names | METTL18 ASTP2 C1orf156 |
| Alternative Gene Names | ASTP2 C1orf156 |
| Alternative Protein Names | Histidine protein methyltransferase 1 homolog (EC 2.1.1.85) (Arsenic-transactivated protein 2) (AsTP2) (Methyltransferase-like protein 18) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 372 |
| Molecular Weight(Da) | 42148 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG |
Background
| Function | FUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3 (PubMed:23349634, PubMed:33693809). Through the methylation of RPL3 regulates the dynamics of pre-rRNA processing, ribosome biogenesis, and translation (PubMed:33693809). {ECO:0000269|PubMed:23349634, ECO:0000269|PubMed:33693809}. |
| Pathway | |
| Protein Families | Methyltransferase superfamily, METTL18 family |
| Tissue Specificity |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |