Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens hydroxysteroid 17-beta dehydrogenase 14 (HSD17B14) (NM_016246). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9BPX1 |
| Entry Name | DHB14_HUMAN |
| Gene Names | HSD17B14 DHRS10 SDR3 SDR47C1 UNQ502/PRO474 |
| Alternative Gene Names | DHRS10 SDR3 SDR47C1 |
| Alternative Protein Names | 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 270 |
| Molecular Weight(Da) | 28317 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS |
Background
| Function | FUNCTION: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}. |
| Pathway | |
| Protein Families | Short-chain dehydrogenases/reductases (SDR) family |
| Tissue Specificity | Highly expressed in brain, placenta, liver and kidney. {ECO:0000269|PubMed:10800688, ECO:0000269|PubMed:17067289}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |