Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens GRB2 binding adaptor protein, transmembrane (GAPT), transcript variant 4 (NM_152687). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q8N292 |
| Entry Name | GAPT_HUMAN |
| Gene Names | GAPT C5orf29 |
| Alternative Gene Names | C5orf29 |
| Alternative Protein Names | Protein GAPT (Growth factor receptor-bound protein 2-binding adapter protein, transmembrane) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 157 |
| Molecular Weight(Da) | 17883 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTFLGPRIIGLRHEISVETQDHKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSEVPQDEDIYILPDSY |
Background
| Function | FUNCTION: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}. |
| Pathway | |
| Protein Families | GAPT family |
| Tissue Specificity | Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells. {ECO:0000269|PubMed:18559951}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |