Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens ECRG4 augurin precursor (ECRG4) (NM_032411). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q9H1Z8 |
| Entry Name | AUGN_HUMAN |
| Gene Names | ECRG4 C2orf40 UNQ761/PRO1508 |
| Alternative Gene Names | C2orf40 |
| Alternative Protein Names | Augurin (Esophageal cancer-related gene 4 protein) (ECRG4) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 148 |
| Molecular Weight(Da) | 17183 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MAASPARPAVLALTGLALLLLLCWGPGGISGNKLKLMLQKREAPVPTKTKVAVDENKAKEFLGSLKRQKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDITYWLNRDRNGHEYYGDYYQRHYDEDSAIGPRSPYGFRHGASVNYDDY |
Background
| Function | FUNCTION: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:D4A540}. |
| Pathway | |
| Protein Families | Augurin family |
| Tissue Specificity | Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level). {ECO:0000269|PubMed:21349154}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |