Specification
| Description | Recombinant protein from the full-length sequence of Homo sapiens dual specificity phosphatase 18 (DUSP18), transcript variant 2 (NM_152511). |
| Organism | Homo sapiens (Human) |
| Expression Host | Human Cells |
| Tag Info | His or DYKDDDDK. Please contact us if you need further information or require specific designed tag. |
| Purity | Greater than 90% by SDS-PAGE gel |
| Uniprot ID | Q8NEJ0 |
| Entry Name | DUS18_HUMAN |
| Gene Names | DUSP18 LMWDSP20 |
| Alternative Gene Names | LMWDSP20 |
| Alternative Protein Names | Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20) |
| Application | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Buffer | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg) |
| Length | 188 |
| Molecular Weight(Da) | 21066 |
| Protein Sequence | (The sequence of expressed protein may have some variation from the sequence shown below. Please contact us for the exact sequence.) MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTLYEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMVSSPVGMIPDIYEKEVRLMIPL |
Background
| Function | FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}. |
| Pathway | |
| Protein Families | Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily |
| Tissue Specificity | Widely expressed with highest levels in liver, brain, ovary and testis. {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}. |
QC Data
| Note | Please contact us for QC Data |
| Product Image (Reference Only) |  |